University of Alberta
Home Research Our Lab People Publications Surroundings Contact Us

Selected publications on Huntington's disease:

Di Pardo A, Maglione V, Alpaugh M, Horkey M, Atwal RS, Sassone J, Ciammola A., Steffan JS, Foud K, Truant R and Sipione S(2011) Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice. PNAS In press.

Atwal RS, Desmond CR, Caron N, Maiuri T, Xia J, Sipione S and Truant R. (2011) Huntingtin phosphorylation in N17 affects toxicity, aggregation, localization and can be specifically modulated by kinase inhibitors. Nature Chemical Biology, 7(7):453-60.

Maglione V, Marchi P, Di Pardo A, Lingrell S, Horkey M, Tidmarsh E and Sipione S. (2010) Impaired ganglioside metabolism in Huntington's disease and neuroprotective role of GM1. J Neurosci. 30(11):4072-80.

Posse de Chaves E and Sipione S. (2009) Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction. FEBS Lett. Dec 17 [Epub ahead of print].

Sassone J, Colciago C. Marchi P, Ascardi C, Alberti L, Di Pardo, A., Zippel R., Sipione S, Silani V. and Ciammola A. (2010) Mutant huntingtin induces activation of Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3) Cell Death and Disease 1(1):e7.

Battaglia G., Cannella M., Riozzi B., Orobello S., Maat-Schieman M., Aronica E., Busceti C., Ciarmiello A., Andrea S., Sassone J., Ciammola A.,Sipione S, Bruno V., Nicoletti F., Squitieri F. (2010) Early defect of transforming growth factor b-1 formation in Huntington's disease. J Cell Mol Med 15(3):555-571.

Valenza M, Rigamonti D, Goffredo D, Zuccato C, Fenu S, Jamot L, Strand A, Tarditi A, Woodman B, Racchi M, Mariotti C, Di Donato S, Corsini A,Bates G, Pruss R, Olson JM, Sipione S, Tartari M, Cattaneo E. (2005) Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease. J Neurosci. 25(43):9932-9.

Kooperberg C, Sipione S, LeBlanc M, Strand AD, Cattaneo E, Olson JM. (2002) Evaluating test statistics to select interesting genes in microarray experiments. Hum Mol Genet. 11(19):2223-32.

Sipione S, Rigamonti D, Valenza M, Zuccato C, Conti L, Pritchard J, Kooperberg C, Olson JM, Cattaneo E. (2002) Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses. Hum Mol Genet. 11(17):1953-65.

Sipione S, Cattaneo E. (2001) Modeling Huntington's disease in cells, flies, and mice. Mol Neurobiol., 23(1):21-51.

Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, Timmusk T, Sipione S, Cattaneo E. (2001) Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science, 293(5529):493-8.

Cattaneo E, Rigamonti D, Goffredo D, Zuccato C, Squitieri F, Sipione S. (2001) Loss of normal huntingtin function: new developments in Huntington's disease research. Trends Neurosci. 24(3):182-8.

Varani K, Rigamonti D, Sipione S, Camurri A, Borea PA, Cattabeni F, Abbracchio MP, Cattaneo (2001) Aberrant amplification of A(2A) receptor signaling in striatal cells expressing mutant huntingtin. FASEB J. 15(7):1245-7.

Conti L, Sipione S, Magrassi L, Bonfanti L, Rigamonti D, Pettirossi V, Peschanski M, Haddad B, Pelicci P, Milanesi G, Pelicci G, Cattaneo E. (2001) Shc signaling in differentiating neural progenitor cells. Nat Neurosci. 4(6):579-86.

Rigamonti D, Sipione S*, Goffredo D, Zuccato C, Fossale E, Cattaneo E. (2001) Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing. J Biol Chem., 276(18):14545-8. *Co-first author.

Ehrlich ME, Conti L, Toselli M, Taglietti L, Fiorillo E, Taglietti V, Ivkovic S, Guinea B, Tranberg A, Sipione S, Rigamonti D, Cattaneo E. (2001) ST14A cells have properties of a medium-size spiny neuron. Exp Neurol. Feb;167(2):215-26.

Rigamonti D, Bauer JH, De-Fraja C, Conti L, Sipione S, Sciorati C, Clementi E, Hackam A, Hayden MR, Li Y, Cooper JK, Ross CA, Govoni S, Vincenz C, Cattaneo E. (2000) Wild-type huntingtin protects from apoptosis upstream of caspase-3. J Neurosci. 20(10):3705-13.

Sipione S, Cattaneo E. (2002) Modeling brain pathologies using neural stem cells. In Methods Mol Biol., 198:245-62.

Other publications from Simonetta Sipione:

Dai XQ, Kolic J, Marchi P, Sipione S, Macdonald PE. (2009) SUMOylation regulates Kv2.1 and modulates pancreatic {beta}-cell excitability. J Cell Sci. 2009 122(Pt 6):775-9.

Sipione S, Simmen KC, Lord S, Motyka B, Ewen C, Shostak I, Rayat GR, Dufour JM, Korbutt GS, Rajotte RV and Bleackley RC (2006). Identification of a novel human granzyme B inhibitor secreted by cultured Sertoli cells. J. Immunol., 177(8):5051-8.

Sipione S, Ewen C., Shostak I, Michalak M and Bleackley R.C. Impaired cytolytic activity in calreticulin-deficient cytotoxic T cell (2005).
J.Immunol, 174(6):3212-9

Street CN, Sipione S, Helms L, Binette T, Rajotte RV, Bleackley RC, Korbutt GS (2004) Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes. Int J Bioch Cell Biol, 36(4):667-83

Sipione S, Eshpeter A, Lyon JG, Korbutt GS, Bleackley RC. (2004) Insulin expressing cells from differentiated embryonic stem cells are not beta cells. Diabetologia, 47(3):499-508

Barresi V, Belluardo N, Sipione S, Mudo� G, Cattaneo E, Condorelli DF. (2003) Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy. Cancer GeneTherapy, 10(5):396-402.

Anfuso CD, Sipione S, Lupo G, Ragusa N, Alberghina M. (2003) Characterization of glycerophosphocholine phosphodiesterase activity and phosphatidylcholine biosynthesis in cultured retinal microcapillary pericytes. Effect of adenosine and endothelin-1. Lipids, 38(1):45-52

Dolinsky VW, Sipione S, Lehner R, Vance DE. (2001) The cloning and expression of a murine triacylglycerol hydrolase cDNA and the structure of its corresponding gene. Biochim Biophys Acta., 1532(3):162-72.

Sipione S, Lupo G, Anfuso CD, Albanese V, Alberghina M. (1996). Phosphatidylcholine synthesis-related enzyme activities of bovine brain microvessels exhibit susceptibility to peroxidation. FEBS Lett., 384(1):19-24.

Anfuso CD, Sipione S, Lupo G, Alberghina M. (1995). Evolutionary comparison of enzyme activities of phosphatidylcholine metabolism in the
nervous system of an invertebrate (Loligo pealei), lower vertebrate (Mustelus canis) and the rat. Comp Biochem Physiol B Biochem Mol Biol., 112(3):493-501.

Alberghina M, Infarinato S, Anfuso CD, Lupo G, Sipione S. (1994) Lipid hydroperoxides induce changes in palmitate uptake across the rat blood-retina and blood-brain barrier. Neurosci Lett., 176(2):247-50.

Anfuso CD, Lupo G, Sipione S, Alberghina M. (1994). Susceptibility of rat retina acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase and CTP:phosphocholine cytidylyltransferase activity to lipid peroxidation and hydroperoxide treatment. FEBS Lett., 347(2-3):123-7.